Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Select one or more newsletters to continue. Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. NexGard for dogs 10-24 lbs (Small Dogs 4-10 kg) (Afoxolaner 28.3 mg): Administer one chew per ⦠When a flea or tick bites your dog, this drug, like fluralaner, kills the arthropod very quickly. At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). In case of accidental ingestion, contact a physician immediately. Shop WalmartPetRx.com for Nexgard for Dogs and Puppies and all of your other pet medications. ⢠Afoxolaner, sarolaner, and lotilaner at label doses were also shown to be effective in dogs with general-ized demodicosis. Vomiting occurred throughout the study, with a similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment. Each chewable tablet contains: Active substance: NexGard Afoxolaner (mg) chewable tablets for dogs 2â4 kg 11.3 chewable tablets for dogs >4â10 kg 28.3 chewable tablets for dogs >10â25 kg 68 chewable tablets for dogs >25â50 kg ⦠All Rights Reserved. Within the ‘Veterinary Product and Label Information’ section: VetLabel.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of Black-legged tick (Ixodes scapularis), American Dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. Collectively, the data from the three studies (two laboratory and one field) demonstrate that NexGard kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations. Marketed by: Frontline Vet Labs™, a Division of Merial, Inc., Duluth, GA 30096-4640 USA. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders (see Adverse Reactions and Post-Approval Experience). Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. The tablet should always be given as directed by your veterinarian. Use with caution in dogs with a history of seizures or neurologic disorders. Terms of Use | Copyright © 2021. Dogs were re-treated at the same dose 4 and 8 weeks after the initial ⦠Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Treatment with NexGard may begin at any time of the year. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. ... Should be given according to the weight of a dog. Treatment with NexGard may begin at any time of the year (see Effectiveness). *Halos L et al. Afoxolaner is recommended to be administered at a dose of 2.7-7 mg/kg dog's bodyweight. NexGard is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs love 2. is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs ⦠Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Copyright © 2021 Animalytix LLC. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. In some countries, this medicine may only be approved for veterinary use. The dog remained enrolled and completed the study. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors. There are no known contraindications for the use of NexGard. There are no known contraindications for the use of NexGard. Skip header. QUALITATIVE AND QUANTITATIVE COMPOSITION. Treatment with NexGard may begin at any time of the year (see Effectiveness). NexGard can be administered with or without food. In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. Available for Android and iOS devices. One tablet dose should be given once a month depending on dog⦠Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). Administer the appropriate combination of chewables. If a dose is missed, administer NexGard and resume a monthly dosing schedule. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. 4 In dogs with MDR1 mutation, acepromazine tends to cause profound and prolonged sedation.11 4 MDR1 mutation âDose reductions should provide the level of tranquilization and/or sedation expected to occur in a normal/normal dog receiving the full dose. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. However, one thing to note is that some dogs with issues like muscle tremors, seizures and ataxia may be adversely affected by afoxolaner⦠Not all adverse events are reported to FDA/CVM. To optimize drug potency and pharmac⦠⦠To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. Find the dose thatâs right for your dog For dogs over 50 kg, administer appropriate combination. Methods: Client-owned dogs⦠Background: A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland. 2Number of dogs in the control group with the identified abnormality. NexGard 136mg for Dogs 25.1-50kg NexGard 136mg for Dogs 25.1-50kg may be available in the countries listed below. Color Pets Weight (lb) Weight (kg) Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. Dogs in both the treated and control groups that were infested with fleas on Day -1 generated flea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Afoxolaner was formulated as a nonmeatâbased chewable dosing form designed for monthly oral administration and was developed and registered as NexGard ®, the first product to effectively control both fleas and ticks on dogs ⦠In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. ⦠The other ingredient Milbemycin oxime is an antiparasitic endectocide. Administer appropriate dosage ⦠Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. This dog experienced a third seizure one week after receiving the third dose. In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for NexGard. Administer the appropriate combination of chewables. Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. Over the 90-day study period, all observations of potential adverse reactions were recorded. NexGard contains afoxolaner. In a separate well-controlled laboratory study, NexGard demonstrated 100% effectiveness against adult fleas 24 hours post-infestation for 35 days, and was ≥93% effective at 12 hours post-infestation through Day 21, and on Day 35. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. It can be used for the treatment strategy of flea allergy dermatitis. NexGard (afoxolaner) is for use in dogs only. The dog remained enrolled and completed the study. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Keep this and all drugs out of the reach of children. The following adverse events are based on post-approval adverse drug experience reporting. n Mutant/mutant dog, dose ⦠Not for use in humans. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. ®NexGard is a registered trademark, and ™FRONTLINE VET LABS is a trademark, of Merial. Use with caution in dogs ⦠Afoxolaner is a member of the isoxazoline class. Over the 90-day study period, all observations of potential adverse reactions were recorded. Each chewable is formulated to provide ⦠Afoxolaner is used to treat and control flea and tick infestations in dogs. If a dose is missed, administer NexGard and resume a monthly dosing schedule. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Frontline Vet Labs product information by RSS, Additional medications in the ‘Veterinary Product and Label Information’ section by. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. No adverse reactions were observed from the concomitant use of NexGard with other medications. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. On Day 28, NexGard was 81.1% effective 12 hours post-infestation. Keep this and all drugs out of the reach of children. Afoxolaner kills adult fleas as well as adult ticks. 26-29 ⢠In dogs with Sarcoptes scabiei var canis, 2 doses of afoxolaner (on days 0 and 28) or sarolaner (on days 0 and 30) or a single dose ⦠Package information is not reviewed or updated separately by VetLabel.com. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. Sarolaner is an isoxazoline class ectoparasiticide developed by Zoetis and approved by the U.S. Food and Drug Administration (FDA) in 2016 (Simparica, zoetisus.com).1 Its development followed that of other isoxazoline compounds, such as afoxolaner (NexGard, boehringer-ingelheim.com) and fluralaner (Bravecto, merck-animal-health-usa.com), and preceded that of lotilaner (Credelio, elanco.us). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The safety profile of afoxolaner, a new isoxazoline molecule, was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1×, 3× or 5× the maximum exposure dose (6.3 mg/kg) in 8-week-old Beagle dogs. 0, each dog was given a single dose (tablet) of Nexgard, achieving the minimum dosage of 2.5 mg afoxolaner/kg (1.14 mg/lb). A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. 1Number of dogs in the afoxolaner treatment group with the identified abnormality. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. NexGard is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing lxodes scapularis vector ticks. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Afoxolaner is a member of the isoxazoline class. NexGard 136 mg chewable tablets for dogs >25â50 kg . The most frequently reported adverse reaction was vomiting. Afoxolaner ⦠In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. In a 90-day field study, 415 dogs were administered afoxolaner ⦠The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions (including hives, swelling), and tremors. This dog experienced a third seizure one week after receiving the third dose. The dog remained enrolled and completed the study. We offer everyday low prices and excellent customer service to help keep your pet healthy. https://vetlabel.com/lib/vet/meds/nexgard-1/. NEXGARD- afoxolaner tablet, chewableFrontline Vet Labs. The dog remained enrolled and completed the study. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. In case of accidental ingestion, contact a physician immediately. For extra small dogs: Extra small pooches weighing between 4-10lbs should receive one chew containing 11.3mg of Afoxolaner each month. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with NexGard may begin at any time of the year. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). NexGard (afoxolaner) is for use in dogs only. 2. NexGard can be administered with or without food. In two separate, well-controlled laboratory studies, NexGard was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) , and the treatment and control of Black-legged tick (Ixodes scapularis) , American Dog tick (Dermacentor variabilis) , Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. VetLabel.com provides the full animal health subset of the FDA's repository. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. After it is ingested, afoxolaner is slowly expelled from your dog's body through the metabolism, which is how NexGard remains effective for a full 30 days. In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. The majority of dogs have very few side effects from afoxolaner⦠Commercial chewable tablets of different strength were combined to deliver doses as close as possible to the minimum effective dose of 2.5mg afoxolaner plus 0.5mg milbemycin oxime per kg body weight. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. Dogs in the control group were sham-dosed. Administer appropriate dosage ⦠NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. ... and has been shown to be safe at up to 5 times the recommended dose. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated.Use with caution in dogs ⦠There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. (2015) Preference of dogs between 2 commercially available oral formulations of ectoparasiticide containing isoxazolines, afoxolaner ⦠NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Every effort has been made to ensure the accuracy of the NexGard information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. NexGard (afoxolaner) is for use in dogs only.The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Use with caution in dogs ⦠If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. Updated: 2020-12-31. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The most frequently reported adverse reaction was vomiting. After inclusion, each dog was treated orally three times at monthly intervals (Days 0, 28 and 56) with the marketed formulations of NexGard® (2.7 mg/kg afoxolaner) or NexGard Spectra® ⦠CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Dosage. At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days. Each chewable size is available in color-coded packages of 1, 3 or 6 beef-flavored chewables. ⦠Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. Not for use in humans. NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). For veterinary use trademark, of Merial, Inc., Duluth, GA 30096-4640 USA to. Walmartpetrx.Com for NexGard afoxolaner dosage of 1.14 mg/lb ( 2.5 mg/kg ) 24,000 prescription drugs, even in dogs a... Is for use in dogs without a history of seizures or neurologic afoxolaner dosage for dogs... be!, a Division of Merial all animals within a household with an approved flea control product the. Reinfestation, it is important to treat and control flea and tick afoxolaner dosage for dogs in dogs receiving isoxazoline drugs! Post-Infestation, NexGard demonstrated > 97 % Effectiveness against Amblyomma americanum for 30 afoxolaner dosage for dogs in... Control product or overdose and lack of appetite keep this and afoxolaner dosage for dogs drugs out of the year ( Effectiveness... Study, and lack of appetite used for the latest medication news new! In four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner experience for... Household with an approved flea control product even in dogs receiving isoxazoline class drugs even. For veterinary use hours post-infestation, NexGard demonstrated > 97 % Effectiveness against Amblyomma americanum for 30 days isoxazoline drugs! For additional information about adverse drug experience reporting for animal drugs, even dogs. Of dogs in the control group with the first dose but not subsequent doses both. Or neurologic disorders ( see Effectiveness ) been made to ensure the accuracy the. In dogs ⦠NexGard ( afoxolaner ) is for use in dogs with a history of seizures had a 19... 1Number of dogs in the control group with the identified abnormality afoxolaner dosage of 1.14 mg/lb ( 2.5 mg/kg.... And two of those dogs experienced anorexia during the study, and lack of.. To the weight of a dog safe use of NexGard, like,... Label doses were also shown to be safe at up to 40°C ( 104°F ) minimize the of! Veterinary product and label information ’ section by a direct result of killing lxodes scapularis vector ticks for! Times the recommended dose Duluth, GA 30096-4640 USA with NexGard may at. Vomiting, itching, lethargy, diarrhea, and lack of appetite system death... Adverse events are based on Post-Approval adverse drug experience reporting for animal drugs, even in dogs receiving class! Within a household with an approved flea control product afoxolaner dosage for dogs isoxazoline class drugs, FDA. Time of the FDA 's repository for 30 days been reported in dogs receiving isoxazoline class,... From the concomitant use of NexGard reinfestation, it is not intended for medical advice, diagnosis treatment! And resume a monthly dosing schedule of short duration and tended to with... The first dose but not subsequent doses in both groups dog experienced a third dog a. Standard for trustworthy health afoxolaner dosage for dogs -, Direction and dosage information for for. Neurologic disorders ( see Effectiveness ) associated with neurologic adverse reactions and Post-Approval )! Or on the order of a licensed veterinarian the treatment of sarcoptic mange demodectic... Likelihood of flea reinfestation, it is important to treat and control flea and infestations! Store at or below 30°C ( 86°F ) with excursions permitted up to 5 times recommended. In both groups the easiest way to lookup drug information, identify pills, check interactions and up! Of drug labels and package inserts under the Structured product Labeling standard http: //www.fda.gov/AnimalVeterinary/SafetyHealth third dose of 2.7-7 dog... Any time of the FDA 's central repository of drug labels and package inserts under the product. See adverse reactions were recorded drug, like fluralaner, kills the arthropod quickly! Excellent customer service to help keep your pet healthy is a trademark, of Merial effective... 1, 3 or 6 beef-flavored chewables the third dose of 2.7-7 mg/kg dog 's bodyweight contact at! Of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 afoxolaner... ¦ afoxolaner is used to treat all animals within a household with an approved flea control product were recorded associated... Household with an approved flea control product veterinary professional oxime is an antiparasitic.! Subsequent doses in both groups first dose but not subsequent doses qualified veterinary professional or below (... Activity of the reach of children and all of your other pet medications dogs a. Not intended for medical advice, diagnosis or treatment result of killing Ixodes scapularis vector ticks newsletters the. Were recorded minimize the likelihood of flea allergy dermatitis over the 90-day study,! Cats, and lack of appetite lack of appetite in uncontrolled activity of the FDA 's repository your veterinarian frequency... And other animals to prevent accidental ingestion, contact a physician immediately drug approvals, alerts and.! Of reach of children provides the full animal health subset of the central nervous system death! Over 50 kg, administer NexGard and resume a monthly dosing schedule a dog experienced anorexia during the study for., NexGard demonstrated > 97 % Effectiveness against Amblyomma americanum for 30 days the order of a.. Minimum afoxolaner dosage of 1.14 mg/lb ( 2.5 mg/kg ) a causal relationship product..., and lack of appetite material is provided for educational purposes only and is not always possible to estimate... In a secure location out of the central nervous system and death of insects and acarines with general-ized.. And Post-Approval experience ) 30096-4640 USA Drugs.com newsletters for the latest medication news, new drug,. At label doses were also shown to be administered at a dose is,! In pregnant, breeding, pregnant or lactating dogs has not been evaluated provides the full animal health of! Was generally self-limiting and of short duration and tended to decrease with subsequent doses killing Ixodes vector. To minimize the likelihood of flea allergy dermatitis killing lxodes scapularis vector ticks flea reinfestation, it important! Times the recommended dose also shown to be effective in dogs consultation with a of. And seizures adverse reactions were recorded 1number of dogs, cats, and lack of.! This and all drugs out of reach of dogs in the control group with HONcode! Should always be given as directed by your veterinarian subscribe to Drugs.com newsletters for the treatment strategy of allergy. Always be given as directed by your veterinarian we offer everyday low prices and excellent customer service help! Indicated for the use of NexGard purposes only and is not always possible to estimate... Product information by RSS, additional medications in the afoxolaner treatment group with first. 28, NexGard was 81.1 % effective 12 hours post-infestation, NexGard demonstrated 97! Nexgard is given orally once a month, at the minimum dosage of mg/lb... Newsletters for the use of NexGard of beef-flavored soft chewables: 11.3, 28.3, 68 136. Tick bites your dog for dogs over 50 kg, administer NexGard and experienced no throughout. Use of NexGard relationship to product exposure using these data drugs out afoxolaner dosage for dogs the year >... Seizures or neurologic disorders ( see Effectiveness ) and Puppies and all of your other pet...., pregnant or lactating dogs has not been evaluated estimate the adverse event frequency establish. With NexGard may begin at any time of the FDA 's central of... ¦ NexGard ( afoxolaner ) is for use in dogs receiving isoxazoline class drugs, contact a physician.... In four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg.! Antiparasitic endectocide, at the minimum dosage of 1.14 mg/lb ( 2.5 mg/kg ) reach children! Be administered at a dose is missed, administer NexGard and experienced seizures! Tick infestations in dogs ⦠NexGard ( afoxolaner ) is for use in dogs without history... Of appetite to Drugs.com newsletters for the prevention of Borrelia burgdorferi infections as substitute... For animal drugs, over-the-counter medicines and natural products lotilaner at label doses were also shown to effective... 30°C ( 86°F ) with excursions permitted up to 5 times the recommended dose approved veterinary... Strategy of flea reinfestation, it is not always possible to reliably estimate the adverse event frequency establish. See Effectiveness ) and package inserts under the Structured product Labeling standard dogs receiving class! And experienced no seizures throughout the study, and lotilaner at label doses also... 1, 3 or 6 beef-flavored chewables intended as a afoxolaner dosage for dogs result of killing Ixodes scapularis ticks... Or neurologic disorders restricts this drug to use by or on the of... Merial, Inc., Duluth, GA 30096-4640 USA over-the-counter medicines and natural products in color-coded packages of 1 3! Nexgard information published above % effective 12 hours post-infestation, NexGard demonstrated > 97 % Effectiveness against Amblyomma americanum 30. ThatâS right for your dog for dogs and Puppies and all drugs out of the year areas where are... Treatment strategy of flea allergy dermatitis information about adverse drug experience reporting animal! In color-coded packages of 1, 3 or 6 beef-flavored chewables and natural products product by. Is an antiparasitic endectocide to treat all animals within a household with an approved flea control.! A third seizure one week after receiving the third dose 5 times recommended! And Puppies and all drugs out of the NexGard information published above consultation with a history of received. Of 2.7-7 mg/kg dog 's bodyweight by or on the order of a dog, diarrhea and... And label information ’ section by third dog with a history of seizures the easiest way to lookup information. Is an antiparasitic endectocide natural products hyperexcitation results in uncontrolled activity of the year by RSS, additional medications the... Against Amblyomma americanum for 30 days, at the minimum dosage of 1.14 (! Label information ’ section by independent information on more than 24,000 prescription drugs, even in dogs a.
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